Samantha was born in Adelaide, South Australia, she has a brother and a sister, Jessica and Daniel. She attended Brigidine College Randwick, . She completed her Masters at Sydney University in 2004 and then decided after graduation she wanted to be an actress. In 2001 Samantha graduated BA in Drama, History and Education from the Australian Catholic University and she has trained at NIDA, Actors Studio New York, Stella Adler Institute Los Angeles, Ivana Chubbick Studio, On Camera Connections and ATYP. Her father is actor and director John Noble. As well as being an actress, Samantha is also a professional singer, director and writer. She teaches acting at numerous film schools in Sydney and Los Angeles. She plays the piano and saxophone. She currently resides in Los Angeles.
Samantha is the face of Fosters Lager in America , Samantha has starred in several TV Series including Home and Away and All Saints, and will play the role of Leah in the 2008 release of the Horror/Thriller movie The Gates of Hell, she has also starred in See No Evil and Gabriel. She has auditioned to Co-Host the Gladiators. Samantha has also featured in several short films including Taxi Ride, How To Hurt, Lost Little Girl and Dead Man's Creek..