Nikki D was the first female rapper signed by Def Jam Recordings. She signed with Def Jam in 1989 and released her debut single "A No No No", in the same year. It was produced by Sam Stever. The single's video featured Flavor Flav and computerized images of the other Def Jam artist. Later Nikki D released the more commercially acceptable song, "Daddy's Little Girl" some two years later, which debuted at #1 on the Billboard Hot 100 and R&B charts.
Before this Nikki D was on tour in Europe for a year with fellow R&B artist Alyson Williams. Nikki D recorded songs with Hold my nuts Moby, Queen Latifah on the Set It Off soundtrack, with Red Man for his Muddy Waters album, EPMD, Naughty By Nature, Flavor Unit and Susan Vega.
In 1998 Nikki D was the vice president Of A&R at Flavor Unit Records for two years. Today she is the marketing manager at Phat Fashions, the apparel company that houses Phat Farm, Baby Phat, and Atman.