She was one of the top models of the 1980s, identified along with Carol Alt, Christie Brinkley, Kelly Emberg, Esme, Iman, and Paulina Porizkova. In 1983 she became the face of Revlon's premium Ultima II line, replacing Lauren Hutton.
In the 1990s she was model/spokeswoman for Hemorid brand hemorrhoid cream. She later did commercials for Preparation H, another hemorrhoid cream, and Monistat yeast infection ointment.
Alexis hosted health shows in the early 1990s on the Family Channel and Lifetime, and is a marathoner. She appeared in the 1998 movie Holy Man with Eddie Murphy.
In 2005, she appeared on VH1's reality competition But Can They Sing?, where celebrities, who have never sung before, get the chance to perform in front of an audience. Alexis was eliminated in week two.
In 2008, Alexis was the host of a new modeling competition She's Got the Look for TV Land.
She is married to Ron Duguay with whom she has three children. She has two more children from a a previous marriage. She presently resides in Glen Allen, Virginia.
A born-again Christian, she is very vocal about her faith in God and is a pro-life activist.