In 1994 Bruno earned a Bachelor of Science degree in Environmental Engineering from MIT. While there he played varsity football as a linebacker for the MIT football team. In high school he was a nationally ranked wrestler and competed in the AAU Junior Olympic Games several times. His brother is actor Chris Bruno. His father's name is Scott Bruno.

In 1989 he was a contestant on American Gladiators TV show.

While working as a model for Calvin Klein, Dylan made his TV acting debut in 1995 on the NBC series High Sierra Search and Rescue. He made his film acting debut in Naked Ambition in 1997.

In 1998, he had small roles in Saving Private Ryan, When Trumpets Fade, and Where The Heart Is (2000). He co-starred in The Rage: Carrie 2 in 1999. He portrayed an L.A. cop in The One in 2001, and Harry "Blaine" Mayhugh, Jr., in The Pennsylvania Miners Story in 2002.

Bruno has also done voice-over work for several products such as Bacardi Silver, Coors Light, Virtual Boy, and Sony Handycam.