Azura Skye was born in her grandmother's home in Northridge, California. Her parents being amateur gemologists, she was named after azurite, a semi-precious mineral. She started her career as a stage actress at the age of three and toured Europe with the Santa Monica Playhouse theatre group at the age of eleven. She received her education at the Brentwood School.

Skye made her first TV appearance on the show Total Security in 1997. Then she played a couple of smaller parts on Touched by an Angel and Chicago Hope, and made appearances in a number of television movies before she was cast for the role as "Jane" in Zoe, Duncan, Jack and Jane in 1999. Zoe..., as the showed was renamed for the second season, was a shortlived (two seasons) sit com about four teenagers - Skye's character being one of them. In 2000, the same year that Zoe... ended, Skye's first major movie production premiered. In 28 Days she starred alongside Sandra Bullock and Viggo Mortensen.

Two years later, in 2002, Skye appeared in two episodes of the cult TV series Buffy the Vampire Slayer. In the episode "Help" she plays Cassie Newton, a teen girl at Sunnydale High who possesses the power of precognition and who foresees her own death, and whom Buffy tries to help. In the episode "Conversations with Dead People" she plays an incarnation of the First Evil, in the form and shape of Cassie, who attempts to convince Willow to commit suicide, by pretending to bring a message from her dead girlfriend Tara.

During this time she also appeared in other projects, doing smaller parts. She has played Susie Keaton in four episodes of CSI: Miami and has made guest appearances in shows such as Smallville and Judging Amy. Skye has also played parts in movies like Bandits (with Bruce Willis and Cate Blanchett), The Salton Sea (with Val Kilmer) and Red Dragon (with Anthony Hopkins).

Azura Skye's most recent movie part is that of "Ruby Bates", in the 2006 drama Heavens Fall. In 2007 she will star as "Sara" in Like Moles, Like Rats and will have a small part in What We Do Is Secret and a major part in the American remake of the Japanese movie One Missed Call, which is expected to premiere in America on August 24.

Her most recent TV appearances are as "Skyler" in three 2006 episodes of The Minor Accomplishments of Jackie Woodman, an eight-part comedy series about the not-so-glamorous side of Hollywood, and as the Voice of "Veronica" in an episode of "American Dad".