Wilson-Jones was educated at Sir William Perkins's School, a private all girls school in Chertsey, Surrey, where she was deputy head girl. She has two sisters, Charlotte (who once appeared on Blind Date) and Alex and a brother, Nick
Her most in the Sky One UK television series Hex, as Jo Watkins, and the Channel 4 adaptation of the novel Sugar Rush, as Anna. She has also appeared in As If, Monarch of the Glen, Spaced , Waterloo Road and Ashes To Ashes.
Wilson-Jones has also featured in the ITV parapsychology drama afterlife in which she plays Jude Bridge, the ex-wife of Robert Bridge (played by Andrew Lincoln) and from June 2007 she appeared as Sally in an ITV drama serial The Time of Your Life.