Adamari López started her career at the age of six, alongside legendary Puerto Rican actress Johanna Rosaly and Venezuelan singer José Luis Rodríguez, El Puma, in the Telemundo Canal 2 production of the Cristina Bazan soap opera. Her talent indicated a future superstar. WAPA-TV next chose her to play Iris Chacon and Daniel Guerrero's daughter in Yo Se Que Mentia. She was then nine years old, and was given one of the most important roles of the story. López became a household name. A short, two chapter appearance on Vivir Para Ti followed in 1983, and after that, López decided to dedicate herself to her studies. She holds a B.A. in Communications from University of the Sacred Heart in Puerto Rico.

After reaching the age of majority, she came back, participating in several plays at Puerto Rico's Teatro Tapia, San Juan's premier and oldest theater, and getting the attention of Mexican producers. She traveled to Mexico next, after the invitation by the producers to try out there, and became a superstar in that country as well, working in many top soap operas, including the national super hit Amigas y Rivales. López also participated in Mujer, Casos de la Vida Real, where she played a victim of rape that later turned lesbian.